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KMID : 1035620180060010014
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Allergy Asthma & Respiratory Disease
2018 Volume.6 No. 1 p.14 ~ p.25
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The KAAACI Standardization Committee Report on the procedure and application of the bronchial provocation tests
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Lim Kyung-Hwan
Kim Min-Hye
Yang Min-Suk
Song Woo-Jung
Jung Jae-Woo
Lee Jeong-Min
Suh Dong-In
Shin Yoo-Seob
Kwon Jae-Woo
Kim Sae-Hoon
Kim Sang-Heon
Lee Byung-Jae
Cho Sang-Heon
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Abstract
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Bronchial provocation tests are of value in the evaluation of airway hyperresponsiveness. Nonspecific bronchial challenge (methacholine, mannitol, exercise, etc.) is used when the symptoms, physical examination, and measurements of pulmonary function are unremarkable in the diagnosis of asthma, when a patient is suspected of having occupational asthma or exercise-induced bronchoconstriction (EIB), and when a screening test for asthma or EIB is required for some occupational groups in whom bronchospasm would pose an unacceptable hazard. Methacholine inhalation challenge is most widely used pharmacologic challenge and highly sensitive. For appropriate interpretation of the results of methacholine provocation, it is important to perform the test with the standardized protocol and to recognize that inhalation methods significantly influence the sensitivity of the procedure. Indirect challenges (e.g., mannitol and exercise) correlate with airway inflammation and are more specific but less sensitive for asthma. Indirect provocation tests are used to confirm asthma, to differentiate asthma from other airway diseases, and to evaluate EIB.
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KEYWORD
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Bronchial provocation tests, Methacholine, Mannitol, Exercise test
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